PCR Journal Club

Antiplatelet therapy in patients with conservatively managed spontaneous coronary artery dissection from the multicentre DISCO registry

20 Aug 2021

The aims of this study were to assess the use of antiplatelet drugs in medically treated spontaneous coronary artery dissection (SCAD) patients and to investigate the relationship between single (SAPT) and dual (DAPT) antiplatelet regimens and 1-year patient outcomes.

Reviewer

Ahmet Zengin

Reviewer

Ali Nazmi Calik

Antiplatelet therapy in patients with conservatively managed spontaneous coronary artery dissection from the multicentre DISCO registry

Operator volumes and in-hospital outcomes: an analysis of 7,740 rotational atherectomy procedures from the BCIS national database

05 Jul 2021

Find out more about the results of this analysis which suggest that operator experience may be an important effect modifier in ROTA-PCI.

Reviewer

Nicola Ryan

Operator volumes and in-hospital outcomes: an analysis of 7,740 rotational atherectomy procedures from the BCIS national database

Aspirin versus clopidogrel for chronic maintenance monotherapy after percutaneous coronary intervention (HOST-EXAM): an investigator-initiated, prospective, randomised, open-label, multicentre trial

18 Jun 2021

The HOST-EXAM trial sought to define whether, after DAPT for PCI with DES, clopidogrel monotherapy is associated with improved outcomes compared with aspirin monotherapy.

Reviewer

Daniele Giacoppo

Aspirin vs clopidogrel for chronic maintenance monotherapy after PCI: HOST-EXAM trial

Intravascular lithotripsy for treatment of calcified coronary lesions: patient-level pooled analysis of the Disrupt CAD studies

11 May 2021

Using patient-level data from the Disrupt CAD I, II, III and IV trials, this pooled analysis assesses the efficacy and safety of intravascular lithotripsy in de novo calcified coronary lesions.

Reviewer

Michele Pighi

Reviewer

Nicola Ryan

IVL for treatment of CCL: patient-level pooled analysis of the Disrupt CAD studies

Novel Supreme DES with early synchronized antiproliferative drug delivery to inhibit smooth muscle cell proliferation after DES implantation in coronary artery disease: results of the PIONEER III randomized clinical trial

06 May 2021

The PIONEER III trial aims to assess the effectiveness and safety of the biodegradable-polymer sirolimus-eluting Supreme stent compared to durable-polymer everolimus-eluting stent (Xience or Promus), completely releasing the drug by 120 days.

Reviewer

Daniele Giacoppo

Novel Supreme DES with early synchronized antiproliferative drug delivery to inhibit SMC proliferation after DES implantation in CAD: results of the PIONEER III trial

Impact of post-stenting fractional flow reserve on long-term clinical outcomes - The FFR-SEARCH Study

29 Apr 2021

The objective of this analysis was to prospectively investigate the clinical impact of post-PCI FFR values on long-term clinical outcomes.

Reviewer

Michele Pighi

$Impact of post-stenting fractional flow reserve on long-term clinical outcomes - The FFR-SEARCH Study$

Uninterrupted oral anticoagulant therapy in patients undergoing unplanned percutaneous coronary intervention

13 Apr 2021

This large-scale analysis sought to compare interrupted and uninterrupted OAC therapy in patients taking OAC undergoing unplanned coronary angiography or PCI for suspected acute coronary syndrome.

Reviewer

Daniele Giacoppo

Identification of vulnerable plaques and patients by intracoronary near-infrared spectroscopy and ultrasound (PROSPECT II)

29 Mar 2021

This is the first prospective natural history study to evaluate the utility of comprehensive intravascular imaging with both IVUS and NIRS in predicting future adverse events following acute myocardial infarction.