Ruxandra Sava
Latest contributions
Routine primary PCI: what can go wrong?
21 May 2026 – From EuroPCR 2026
This session offers an in-depth examination of potential complications during routine primary PCI, focusing on prevention and management strategies. Key learning points include understanding no-reflow phenomena, managing STEMI in post-CABG patients, and handling thrombus burden effectively. Real-world cases illustrate decision-making processes and therapeutic approaches to optimize...
Complex left main patients and PCI
20 May 2026 – From EuroPCR 2026
This session addressed the complexities of left main PCI, focusing on managing hemodynamic uncertainty in high-risk interventions, advanced techniques such as ultra-low contrast rota-tripsy PCI, precise stent positioning, and pragmatic approaches to CHIP cases, emphasizing contrast-sparing strategies and best practice balancing.
NOBLE trial: 10-year outcomes of PCI vs CABG in left main disease
13 Apr 2026
Long-term evidence comparing PCI and CABG for unprotected left main coronary disease has been limited and sometimes conflicting. The 10-year results from the NOBLE trial now provide important clarity on all-cause mortality outcomes with both revascularisation strategies.
Reviewer
Sex-specific outcomes after transcatheter or surgical treatment of aortic valve stenosis: the DEDICATE-DZHK6 trial
30 Mar 2026
Women have long been underrepresented in TAVR trials. This article explores the DEDICATE trial’s sex-specific outcomes after TAVI and SAVR, revealing differences in early stroke risk, procedural challenges, and one-year survival in men and women with aortic stenosis.
Reviewer
Fractional flow reserve to guide revascularisation in patients with coronary artery disease undergoing TAVR
07 Jan 2026
The present analysis compared major adverse cardiac events in patients with significant coronary stenosis (FFR ≤ 0.80 or visual stenosis ≥ 90 %) versus those with non-significant stenosis (FFR > 0.80).
Reviewer
Reviewer
Highlights of science and education in cardiovascular interventional medicine in 2025
22 Dec 2025
Dear Colleagues, dear PCR Companions,
As we welcome a New Year, it is the perfect time to reflect on what we achieved together over the past year - both as a celebration of our collective success and as motivation to continue improving in the year ahead.
2025 was...
Validation of intravascular ultrasound-defined optimal stent expansion criteria for favorable 1-year clinical outcomes
17 Nov 2025
This individual patient data analysis of the three largest RCTs evaluating IVUS-guided stent optimisation showed that an MSA > 5.5 mm2 was associated with reduced TVF at one year.
Reviewer
Reviewer
Outcomes after CABG compared with FFR-guided PCI in patients presenting with acute coronary syndrome
10 Jun 2025
This prespecified analysis of the Fractional Flow Reserve versus Angiography for Multivessel Evaluation (FAME 3) trial examined the impact on cardiovascular outcomes of treatment by CABG versus FFR-guided PCI in patients with three vessel disease (3-VD), stratified by acute (NSTEMI) or chronic coronary syndrome (CCS) presentation.
Reviewer
Reviewer
Effects of proton pump inhibitors on gastrointestinal bleeding and cardiovascular outcomes in myocardial infarction patients treated with DAPT
08 Apr 2025
This large retrospective analysis using data from the Republic of Korea’s Nationwide Health Claims database showed that co-prescription of a PPI in patients treated with DAPT following an AMI was associated with reduced major GI bleeding as well as reduced minor GI bleeding requiring hospitalisation, regardless...
Reviewer
Reviewer
Best companion's case on intravascular lithotripsy
23 May 2025 – From EuroPCR 2025
Join this session focusing on intravascular lithotripsy in challenging cases, emphasizing device and drug synergy, IVUS guidance, and strategies to avoid exacerbating complications. Clinical cases demonstrate management of tough calcified lesions with novel approaches.
Impact of imaging in treatment of bifurcation lesions - Part 1
22 May 2025 – From EuroPCR 2025
Investigate the critical role of intracoronary imaging in the management of bifurcation lesions. This session addresses challenges such as difficult side branch access and lesion complexity, highlighting the importance of strategy over chance. Learn from cases focusing on left main bifurcation, lesion de-calibration, and complex ostial...
Comprehensive diagnosis in chronic coronary syndromes combining angiography and intracoronary testing: the AID-ANGIO study
18 Feb 2025
The authors hypothesized that enriching invasive coronary angiography (ICA) with an advanced invasive diagnosis (AID) strategy would increase the diagnostic yield of obstructive and non-obstructive coronary artery disease (INOCA).
Reviewer
Reviewer
DCB PCI in restenosis and de novo lesions
14 May 2024 – From EuroPCR 2024
This session will feature a series of selected clinical case submissions from EuroPCR 2024, focusing on the use of drug-coated balloons (DCB) in the management of restenosis and de novo coronary lesions. Attendees will have the opportunity to explore various strategies, including the use of a...
Changes of STEMI in young patients
17 May 2023 – From EuroPCR 2023
This session will enable you to gain knowledge about "Changes in ST-segment elevation myocardial infarction (STEMI) in young patients" and explore the implications for diagnosis and treatment through a series of challenging real-life case presentations.
PCR Journal Club team
28 Apr 2022
View the list of The Journal Club members who provide regularly updated information on the newest research material in the field of interventional cardiology.