21719 results

Eugene Braunwald: the world of cardiology and medicine mourns the loss of one of its greatest practitioners

24 Apr 2026

Eugene Braunwald, whose work reshaped cardiovascular medicine into the rigorous, evidence-based discipline we know today, leaves behind an extraordinary scientific legacy. He transformed how we think about the heart: not just as an organ to observe, but as a system to understand, measure, and treat through...

TAVI versus SAVR in aortic stenosis, is the debate still relevant in 2026?

02 Jun 2026

In this discussion, Helge Möllman and Eberhard Grube revisit the ongoing debate between TAVI and surgery in the treatment of aortic stenosis. While TAVI continues to expand into younger and more complex patient populations, they emphasise that the dialogue with cardiac surgery remains essential. They highlight the importance...

CLOSURE-AF: left atrial appendage closure or medical therapy in atrial fibrillation

23 Mar 2026

Catheter-based left atrial appendage closure (LAAC) is widely used as an alternative to oral anticoagulation in atrial fibrillation. But how does it compare with best medical therapy in patients at high risk of both stroke and bleeding? The CLOSURE-AF trial provides new data to inform this...

Reviewer

Salvatore Brugaletta

The Physiology Course Programme is out!

Dive into the newly released Programme. From the fundamental principles, to epicardial and microvascular coronary circulation and hands-on experience.

HOST-EXAM:10-year follow-up of clopidogrel vs aspirin monotherapy in stable CAD after PCI with drug-eluting stent

30 Mar 2026

Nicola Ryan provides her take on the 10-year follow-up of the HOST-EXAM, which was presented by Hyo-Soo Kim at ACC.26 in New Orleans.

Author

Nicola Ryan

PCR London Valves 2026: Promotional kit

Browse the official PCR London Valves promotional materials. Download, share and help spread the word about the Course.

Controlled trial of high-risk coronary intervention with percutaneous left ventricular unloading (CHIP-BCIS3)

01 Apr 2026

Aaysha Cader interviews Divaka Perera on the CHIP-BCIS3 randomised trial, which evaluated whether elective left ventricular (LV) unloading during high-risk PCI improves outcomes in patients with severe LV dysfunction, extensive coronary disease, and complex procedures, as presented at ACC.26 in New Orleans.

Author

Aaysha Cader

Author

Divaka Perera

Aortic stenosis and coronary artery disease: which should be treated first?

18 Jun 2026

In this review, Henryk Dreger explores the complex interplay between aortic stenosis and coronary artery disease, highlighting the latest evidence on PCI timing and its implications for clinical decision-making.

Author

Henryk Dreger

ALL-RISE: A large-scale, global randomized trial of coronary physiology derived from conventional angiography compared with an invasive pressure wire-based approach to guide PCI

28 Mar 2026

Mirvat Al Asnag provides her take on the ALL-RISE randomised trial presented by Ajay J. Kirtane at ACC.26 in New Orleans.

Author

Mirvat Alasnag

Two-year outcomes after transcatheter tricuspid repair without cross-over in the randomised TRI-FR trial

28 Mar 2026

Alex Sticchi interviews Erwan Donal on the 2-year outcomes of the TRI-FR randomised trial evaluating transcatheter tricuspid edge-to-edge repair (T-TEER) versus medical therapy alone, as presented at ACC.26 in New Orleans.

Author

Alessandro Sticchi

Author

Erwan Donal

Impact of device implantation depth on blood flow dynamics after left atrial appendage closure

28 Apr 2026

The study aimed to evaluate the impact of LAAC device implantation depth on local flow characteristics and its association with device-related thrombus using patient-specific computational fluid dynamics.

Reviewer

Alessandro Sticchi

Georges El Hachem

Bad Oeynhausen, Germany

IVUS-guided versus angiography-guided PCI in unprotected left main coronary artery disease – The OPTIMAL trial

31 Mar 2026

Ali Nazmi Calik provides his take on the results of the OPTIMAL trial presented by Luca Testa at ACC.26 in New Orleans.

Author

Ali Nazmi Calik

Rapid CT-guided emergency TAVI-in-TAVI-in-valve for cardiogenic shock with high coronary obstruction risk

14 Apr 2026

An 85-year-old man presented in cardiogenic shock with torrential aortic regurgitation after prior surgical and TAVI valve-in-valve procedures. With high coronary obstruction risk, urgent CT assessment and in-silico simulations guided a rapid redo TAVI-in-TAVI-in-valve implantation, demonstrating that CT-assisted emergency redo-TAVI is feasible and lifesaving in high-risk...

A patient with severe MR and torrential TR

26 May 2026

This case explores the management of severe mitral regurgitation and torrential tricuspid regurgitation in a 71-year-old patient with a complex cardiovascular history.

Author

Stefan Toggweiler

Coronary calcification versus thrombus: a deceptive ambiguity revealed in the aftermath of embolisation

07 Apr 2026

Discriminating between coronary calcification and thrombus in acute settings remains a diagnostic challenge with significant implications for interventional decision-making.

Author

Imran Hanif Hashmi

Author

Minahil Tariq Sheikh

Author

Ahmad Usama Wali

Outcomes in patients with atrial fibrillation randomized to receive LAA closure or oral anticoagulation: Primary results of the CHAMPION-AF clinical trial

28 Mar 2026

During the first Late-Breaking Trial session of the 2026 ACC Congress held in New Orleans, Saibal Kar, principal investigator of the CHAMPION-AF trial, presented the 3-year results of this groundbreaking study, which were simultaneously published in the NEJM (DOI: 10.1056/NEJMoa2517213).

Author

Luigi Biasco

Otar Kvavadze

Graz, Austria

Sex-specific outcomes after transcatheter or surgical treatment of aortic valve stenosis: the DEDICATE-DZHK6 trial

30 Mar 2026

Women have long been underrepresented in TAVR trials. This article explores the DEDICATE trial’s sex-specific outcomes after TAVI and SAVR, revealing differences in early stroke risk, procedural challenges, and one-year survival in men and women with aortic stenosis.

Reviewer

Ruxandra Sava

Concept medical announces preliminary 3-year SIRONA data at Charing Cross Symposium 2026

21 Apr 2026