PCR Journal Club

The purpose of the ROLEX Registry (Revascularization Of LEft main with resolute onyX) was to explore outcomes using a more contemporary drug eluting stent platform which is more suitable for LM PCI.

The new analysis from the COAPT trial indicated that lower secondary mitral regurgitation by TEER was strongly associated with reduced heart failure hospitalization, all-cause mortality, and improved quality of life as compared with a higher degree of residual MR.

Optical Coherence Tomography fractional flow reserve (OCT-FFR) has been shown to correlate well with wire-based FFR; however, clinical outcomes based on OCT-FFR are not well defined. In this retrospective study, the authors sought to investigate the relationship between OCT-FFR and long-term clinical outcomes in ACS. 

Although tricuspid regurgitation has for a long time been “the forgotten valve”, recently there has been a rising awareness of the disease with several important studies investigating its pathophysiology and treatment.

The HOST-REDUCE-POLYTECH-ACS trial was a randomised, parallel-group multicentre trial with a 2x2 factorial design testing two independent hypotheses, one of which was the non-inferiority of durable polymer drug-eluting stents (DP-DES) to biodegradable polymer drug-eluting stents (BP-DES) in patients with ACS. In this post-hoc analysis, the authors...

This sub-analysis of ISCHEMIA has shown that implementation of a simple protocol of optimal medical therapy is a key factor to improve health outcome and practical in real-world settings.

In this post-hoc analysis of the TWILIGHT trial, the authors report the effects of ticagrelor monotherapy compared to ticagrelor and aspirin in patients with prior CABG at least three months post PCI with no adverse events and at least one clinical and one angiographic high-risk feature...

The primary objective of the study was to assess whether an IVUS-based stent optimization provided an incremental value in terms of vessel-related adverse event occurrence in patients presenting with low post-PCI FFR (<0.90).

Wollmuth et al in the RESTORE EF study sought to examine the impact of Impella assisted HRPCI on LV function at 90-day follow-up.