PCR Journal Club

The PCR Journal Club provides a selection of Literature Reviews of top interventional cardiovascular journals world-wide, selected and commented by the PCR Journal Club team.

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Topics: CTO, Stable CAD

61 results

Fractional flow reserve to guide revascularisation in patients with coronary artery disease undergoing TAVR

07 Jan 2026

The present analysis compared major adverse cardiac events in patients with significant coronary stenosis (FFR ≤ 0.80 or visual stenosis ≥ 90 %) versus those with non-significant stenosis (FFR > 0.80).

Ruxandra Sava

Reviewer

Ruxandra Sava
Alessandro Sticchi

Reviewer

Alessandro Sticchi
Fractional flow reserve to guide revascularisation in patients with coronary artery disease undergoing TAVR

Balloon lithotripsy added to conventional preparation before stent implantation in severely calcified coronary lesions

06 Jan 2026

In patients with severely calcified coronary lesions undergoing PCI, the BALI trial evaluated the benefit of the addition of intravascular lithotripsy to conventional lesion preparation on the composite endpoint of procedural failure and target vessel failure.

Nicola Ryan

Reviewer

Nicola Ryan
Balloon lithotripsy added to conventional preparation before stent implantation in severely calcified coronary lesions

Impact of pullback pressure gradient on clinical outcomes after percutaneous coronary interventions

02 Dec 2025

While FFR traditionally reflects the severity of a lesion at a fixed location, PPG incorporates the pullback profile, enabling a more comprehensive understanding of disease distribution.

Emanuele Gallinoro

Reviewer

Emanuele Gallinoro
Nicola Ryan

Reviewer

Nicola Ryan
Impact of PPG on clinical outcomes after PCI

One- versus three-month DAPT after everolimus-eluting stent implantation in diabetic patients at high-bleeding risk: results from the XIENCE Short DAPT programme

17 Jun 2025

This analysis from the XIENCE Short DAPT programme compared the safety and efficacy of one-month versus three-month DAPT in high-bleeding risk patients with and without diabetes mellitus (DM) following PCI with everolimus eluting stents (EES).

Nicola Ryan

Reviewer

Nicola Ryan
1- versus 3-month DAPT after EES implantation in HBR diabetic patients: results from the XIENCE Short DAPT programme

Recurrent events analysis of MASTER DAPT: total ischemic and bleeding events after abbreviated vs prolonged DAPT in HBR patient

04 Jun 2025

This exploratory analysis from the MASTER DAPT trial evaluates the effect of abbreviated versus prolonged DAPT on total ischaemic and bleeding events in high-bleeding-risk patients from the MASTER DAPT trial.

Nicola Ryan

Reviewer

Nicola Ryan
Recurrent events analysis of MASTER DAPT: total ischemic and bleeding events after abbreviated vs prolonged DAPT in HBR patient

Effects of proton pump inhibitors on gastrointestinal bleeding and cardiovascular outcomes in myocardial infarction patients treated with DAPT

08 Apr 2025

This large retrospective analysis using data from the Republic of Korea’s Nationwide Health Claims database showed that co-prescription of a PPI in patients treated with DAPT following an AMI was associated with reduced major GI bleeding as well as reduced minor GI bleeding requiring hospitalisation, regardless...

Ruxandra Sava

Reviewer

Ruxandra Sava
Nicola Ryan

Reviewer

Nicola Ryan
Effects of proton pump inhibitors on gastrointestinal bleeding and cardiovascular outcomes in myocardial infarction patients treated with DAPT

Rotational atherectomy, lithotripsy, or laser for calcified coronary stenosis: the ROLLER COASTR-EPIC22 trial

24 Mar 2025

Due to a lack of randomised evidence, this randomised controlled trial (RCT) aimed to compare the safety and efficacy of IVL and ELCA with RA in treating heavily calcified coronary lesions before drug-eluting stent implantation.

Reviewer

Ali Nazmi Calik

Reviewer

Aaysha Cader
Rotational atherectomy, lithotripsy, or laser for calcified coronary stenosis: the ROLLER COASTR-EPIC22 trial

Comprehensive diagnosis in chronic coronary syndromes combining angiography and intracoronary testing: the AID-ANGIO study

18 Feb 2025

The authors hypothesized that enriching invasive coronary angiography (ICA) with an advanced invasive diagnosis (AID) strategy would increase the diagnostic yield of obstructive and non-obstructive coronary artery disease (INOCA).

Ruxandra Sava

Reviewer

Ruxandra Sava
Nicola Ryan

Reviewer

Nicola Ryan
Comprehensive diagnosis in CCS combining angiography and intracoronary testing AID-ANGIO study

Intravascular ultrasound vs angiography-guided drug-coated balloon angioplasty: the ULTIMATE III trial

13 Jun 2024

The results of this study show that IVUS guidance is associated with less late lumen loss compared to angiography guidance in HBR patients undergoing DCB angioplasty.

Nicola Ryan

Reviewer

Nicola Ryan
Intravascular ultrasound vs angiography-guided drug-coated balloon angioplasty: the ULTIMATE III trial

Influence of pathophysiological patterns of coronary artery disease on immediate percutaneous coronary intervention outcomes

28 May 2024

This study demonstrated, for the first time, that PPG - an index to characterize focal vs. diffuse disease - can predict optimal functional revascularization outcomes (post-PCI FFR ≥ 0.88) more accurately than FFR alone.

Giovanni Occhipinti

Reviewer

Giovanni Occhipinti

Reviewer

Salvatore Brugaletta
Influence of pathophysiological patterns of coronary artery disease on immediate percutaneous coronary intervention outcomes