
Alessandro Sticchi
Latest contributions
What’s new in the 2025 guidance on valvular heart disease - ESC Congress 2025
In this interview, Alex Sticchi speaks with Fabien Praz and Michael Borger, co-chairs of the 2025 ESC/EACTS Valvular Guidelines Task Force. They discuss the major updates, including the central role of multimodality imaging, the lowered age threshold for TAVI, the distinction between atrial and ventricular secondary...

Key updates in valvular heart disease management: insights from the 2025 ESC/EACTS Guidelines
03 Sep 2025
Alex Sticchi provides his take on the new ESC Valvular Guidelines presented at the ESC Congress 2025 in Madrid.

Author

Surgical left atrial appendage occlusion in VHD without AF: OPINION Trial
03 Sep 2025
Alex Sticchi provides his take on the results of the OPINION trial presented by Yang Wang at the ESC Congress 2025 in Madrid.

Author

PCRonline @ ESC Congress 2025: the interventional cardiology perspective!
26 Jul 2025
Stay updated with the latest in interventional cardiology at #ESCCongress 2025!

TAVI new devices
22 May 2025 – From EuroPCR 2025
Explore the latest innovations in transcatheter aortic valve implantation (TAVI) devices with a focus on coronary protection strategies, cerebral embolic protection integration, management of ventricular migration, and overcoming anatomical challenges such as bicuspid and rheumatic valve disease using novel platforms.

When mitral disease is not the only problem on mitral TEER patients
22 May 2025 – From EuroPCR 2025
Explore the multifaceted challenges in patients undergoing mitral TEER when additional mitral and tricuspid pathologies coexist. This session reviews data from the EXPANDed studies on tricuspid regurgitation post-mitral TEER, one-year outcomes based on cardiac damage extent, pulmonary hypertension dynamics, and the long-term mortality causes in this...

Impact of transcatheter or surgical aortic valve performance on 5-year outcomes in patients at ≥ intermediate risk
12 Mar 2025
The objective of this study was to validate standardised clinical criteria for BVD and evaluate its association with mortality and rehospitalisation, thereby guiding optimal valve selection in clinical practice.

Reviewer

Two-year outcomes of transcatheter tricuspid valve edge-to-edge repair for tricuspid regurgitation: The Triluminate pivotal trial
02 Apr 2025
Alex Sticchi interviews Saibal Kar about the two-year results of the Triluminate pivotal trial, unveiled at ACC.25 in Chicago.
After revisiting the one-year findings and outlining the study design, Saibal Kar highlights key takeaways: at two years, TriClip therapy significantly reduced heart failure hospitalisations compared to medical...

Author

Author

Functional or anatomical assessment of non-culprit lesions in acute myocardial infarction
06 Mar 2025
This study demonstrates that OCT-defined TCFA is a superior prognostic marker compared to μQFR for assessing NCLs in AMI patients.

Reviewer

PCRonline @ ACC.25 Scientific Sessions
07 Feb 2025
Live updates on a selection of major Late Breaking Clinical Trials of interest in interventional cardiology presented at the American College of Cardiology 2025 Scientific Sessions #ACC25

Featured cases - Challenging tricuspid interventions (Part 1)
24 Nov 2024 – From PCR London Valves 2024
Immerse yourself in a captivating collection of featured cases showcasing the latest advances in transcatheter tricuspid valve interventions. Witness groundbreaking techniques, including the first TTVR designed to reduce afterload mismatch, the management of atrial embolization, and the use of intracardiac echocardiography. Explore complex anatomies, failed prior...

Left Atrial Appendage Closure after Ablation for Atrial Fibrillation - the OPTION Trial
17 Nov 2024
Alessandro Sticchi provides his take on the OPTION Trial presented at AHA 2024 in Chicago.

Author

AHA 2024: get the interventional cardiology perspective!
13 Nov 2024
Stay up to date with what is new and hot in interventional cardiology at #AHA24 in Chicago.

TRISCEND II trial: Randomized comparison of transcatheter valve replacement vs. optimal medical therapy for severe tricuspid regurgitation
04 Nov 2024
Alex Sticchi provides his take on the results of the TRISCEND II trial presented by Susheel K. Kodali and Suzanne V. Arnold at TCT 2024 in Washington.
Also watch the interview with Susheel K. Kodali

Author

PCR @ TCT 2024 - Get the international perspective!
11 Oct 2024
Thanks to the contribution of a team of interventional cardiologists from around the globe, get the international perspective on Late-breaking Clinical Trials and Science released at TCT 2024 - check out the list below.

TRIGISTRY: Benefit of isolated surgical valve repair or replacement for functional tricuspid regurgitation and long-term outcomes stratified by the TRI-SCORE
31 Aug 2024
Alex Sticchi provides his take on the TRIGISTRY study presented by Julien Dreyfus at the ESC Congress 2024 in London.
Simultaneous publication in European Heart Journal, ehae578

Author

Structural cardiac interventions in patients with heart failure
27 Aug 2024
The review aims to address the unmet needs in heart failure (HF) management, particularly in patients where structural heart disease coexists with HF and limits the effectiveness of guideline-directed medical therapy (GDMT).

Reviewer

OCCUPI - Optical coherence tomography-guided coronary intervention in patients with complex lesions
03 Sep 2024
Alex Sticchi provides his take on the OCCUPI trial presented by Kim Byeong-Keuk at the ESC Congress 2024 in London.

Author

TRI.fr trial - Multicentric randomised evaluation of the transcatheter edge-to-edge repair in the treatment of severe isolated secondary tricuspid regurgitation
31 Aug 2024
Alex Sticchi provides his take on the results of the TRI.FR trial presented by Erwan Donal at the ESC Congress 2024 in London.

Author

PCRonline @ ESC Congress 2024: the interventional cardiology perspective!
26 Jul 2024
What was new and hot in interventional cardiology at #ESCCongress 2024!

Prognostic implications of residual tricuspid regurgitation grading after transcatheter tricuspid valve repair
18 Jun 2024
The take-home message for clinicians is that in the treatment of tricuspid regurgitation, the most frequent valvular disease alongside aortic stenosis, redefining procedural success as a function of the residual degree of TR is crucial.

Reviewer
Reviewer

New York Valves 2024: Everything you need to know in a nutshell
11 Jun 2024
Alex Sticchi provides his take on the trials which were presented at New York Valves 2024, offering a concise summary, a short description and final thoughts.

Author

Calcified lesions: one big challenge; several good options
17 May 2024 – From EuroPCR 2024
This session delves into the management of calcified coronary lesions, presenting various techniques and tools to address this common challenge. It covers topics such as the use of drug-coated balloons, rotational atherectomy, intravascular lithotripsy, and high-pressure non-compliant balloons. The session also includes a meta-analysis on the...

Antiplatelet de-escalation after complex PCI: when and how?
14 May 2024 – From EuroPCR 2024
It is now understood that ischemia is not the only risk to consider, as bleeding also plays a significant role. This is why de-escalation is now recommended for patients with complex PCI, as all de-escalation strategies reduce bleeding risk. Discover more about the three different de-escalation...

Percutaneous coronary intervention versus coronary artery bypass grafting in patients with left main disease with and without diabetes: findings from a pooled analysis of 4 randomized clinical trials
30 Apr 2024
This analysis shows that diabetic patients undergoing revascularization face substantially higher 5-year rates of all-cause mortality, myocardial infarction, repeat revascularizations, and stroke compared to non-diabetic patients.

Reviewer

Reviewer

Self-expanding versus balloon-expandable transcatheter aortic valve replacement in patients with small aortic annuli: Primary outcomes from the randomized SMART Trial
07 Apr 2024
Alessandro Sticchi interviews Howard C. Herrmann about the primary outcomes from the randomized SMART Trial which he presented at ACC.24 in Atlanta.
Patients with severe aortic stenosis and small aortic annuli, typically female and often underrepresented in clinical trials, are at risk for impaired valvular hemodynamics and associated...

Author

Author

PCRonline @ ACC.24 Scientific Sessions
22 Mar 2024
Live updates on a selection of major Late Breaking Clinical Trials of interest in interventional cardiology presented at the American College of Cardiology 2024 Scientific Sessions #ACC24

Effect of alcohol-mediated renal denervation on blood pressure in the presence of antihypertensive drugs: 3-month primary results from the TARGET BP I Randomized Trial
08 Apr 2024
Alessandro Sticchi interviews David E. Kandzari about the results of the Target Bp I Randomized Trial which he presented at ACC.24.
The trial reports mixed results on nerve ablation for high blood pressure with a modest but statistically significant difference in lowered blood pressure at 3 months,...

Author

Author

PARTNER 3 Low-Risk trial: 5-year insights on TAVI vs. SAVR outcomes
Alex Sticchi interviews Martin Leon about the five-year clinical and echocardiographic outcomes from the PARTNER 3 Low-Risk randomized trial, presented at the #TCT23 Congress.
The analysis reveals comparable outcomes for TAVI and SAVR, with nuanced differences favouring each approach. Prof. Leon emphasizes the importance of long-term data...

The mortality burden of untreated aortic stenosis
14 Nov 2023
This study, based on extensive real-world data, aimed to assess mortality rates across different untreated AS severities and AS treatment rates.

Reviewer
Reviewer
