Alessandro Sticchi

Alessandro Sticchi

Interventional cardiologist / Cardiologist
Ospedale Cisanello - Pisa, Italy

Latest contributions

What’s new in the 2025 guidance on valvular heart disease - ESC Congress 2025

In this interview, Alex Sticchi speaks with Fabien Praz and Michael Borger, co-chairs of the 2025 ESC/EACTS Valvular Guidelines Task Force. They discuss the major updates, including the central role of multimodality imaging, the lowered age threshold for TAVI, the distinction between atrial and ventricular secondary...

What’s new in the 2025 guidance on valvular heart disease - ESC Congress 2025

Key updates in valvular heart disease management: insights from the 2025 ESC/EACTS Guidelines

03 Sep 2025

Alex Sticchi provides his take on the new ESC Valvular Guidelines presented at the ESC Congress 2025 in Madrid.

Alessandro Sticchi

Author

Alessandro Sticchi

Surgical left atrial appendage occlusion in VHD without AF: OPINION Trial

03 Sep 2025

Alex Sticchi provides his take on the results of the OPINION trial presented by Yang Wang at the ESC Congress 2025 in Madrid.

Alessandro Sticchi

Author

Alessandro Sticchi

PCRonline @ ESC Congress 2025: the interventional cardiology perspective!

26 Jul 2025

Stay updated with the latest in interventional cardiology at #ESCCongress 2025!

TAVI new devices

22 May 2025 – From EuroPCR 2025

Explore the latest innovations in transcatheter aortic valve implantation (TAVI) devices with a focus on coronary protection strategies, cerebral embolic protection integration, management of ventricular migration, and overcoming anatomical challenges such as bicuspid and rheumatic valve disease using novel platforms.

TAVI new devices

When mitral disease is not the only problem on mitral TEER patients

22 May 2025 – From EuroPCR 2025

Explore the multifaceted challenges in patients undergoing mitral TEER when additional mitral and tricuspid pathologies coexist. This session reviews data from the EXPANDed studies on tricuspid regurgitation post-mitral TEER, one-year outcomes based on cardiac damage extent, pulmonary hypertension dynamics, and the long-term mortality causes in this...

When mitral disease is not the only problem on mitral TEER patients

Impact of transcatheter or surgical aortic valve performance on 5-year outcomes in patients at ≥ intermediate risk

12 Mar 2025

The objective of this study was to validate standardised clinical criteria for BVD and evaluate its association with mortality and rehospitalisation, thereby guiding optimal valve selection in clinical practice.

Alessandro Sticchi

Reviewer

Alessandro Sticchi

Two-year outcomes of transcatheter tricuspid valve edge-to-edge repair for tricuspid regurgitation: The Triluminate pivotal trial

02 Apr 2025

Alex Sticchi interviews Saibal Kar about the two-year results of the Triluminate pivotal trial, unveiled at ACC.25 in Chicago.

After revisiting the one-year findings and outlining the study design, Saibal Kar highlights key takeaways: at two years, TriClip therapy significantly reduced heart failure hospitalisations compared to medical...

Author

Saibal Kar
Alessandro Sticchi

Author

Alessandro Sticchi

Functional or anatomical assessment of non-culprit lesions in acute myocardial infarction

06 Mar 2025

This study demonstrates that OCT-defined TCFA is a superior prognostic marker compared to μQFR for assessing NCLs in AMI patients.

Alessandro Sticchi

Reviewer

Alessandro Sticchi

PCRonline @ ACC.25 Scientific Sessions

07 Feb 2025

Live updates on a selection of major Late Breaking Clinical Trials of interest in interventional cardiology presented at the American College of Cardiology 2025 Scientific Sessions #ACC25

Featured cases - Challenging tricuspid interventions (Part 1)

24 Nov 2024 – From PCR London Valves 2024

Immerse yourself in a captivating collection of featured cases showcasing the latest advances in transcatheter tricuspid valve interventions. Witness groundbreaking techniques, including the first TTVR designed to reduce afterload mismatch, the management of atrial embolization, and the use of intracardiac echocardiography. Explore complex anatomies, failed prior...

Featured cases - Challenging tricuspid interventions (Part 1)

Left Atrial Appendage Closure after Ablation for Atrial Fibrillation - the OPTION Trial

17 Nov 2024

Alessandro Sticchi provides his take on the OPTION Trial presented at AHA 2024 in Chicago.

Alessandro Sticchi

Author

Alessandro Sticchi

AHA 2024: get the interventional cardiology perspective!

13 Nov 2024

Stay up to date with what is new and hot in interventional cardiology at #AHA24 in Chicago.

TRISCEND II trial: Randomized comparison of transcatheter valve replacement vs. optimal medical therapy for severe tricuspid regurgitation

04 Nov 2024

Alex Sticchi provides his take on the results of the TRISCEND II trial presented by Susheel K. Kodali and Suzanne V. Arnold at TCT 2024 in Washington.

Also watch the interview with Susheel K. Kodali

Alessandro Sticchi

Author

Alessandro Sticchi

PCR @ TCT 2024 - Get the international perspective!

11 Oct 2024

Thanks to the contribution of a team of interventional cardiologists from around the globe, get the international perspective on Late-breaking Clinical Trials and Science released at TCT 2024 - check out the list below.

TRIGISTRY: Benefit of isolated surgical valve repair or replacement for functional tricuspid regurgitation and long-term outcomes stratified by the TRI-SCORE

31 Aug 2024

Alex Sticchi provides his take on the TRIGISTRY study presented by Julien Dreyfus at the ESC Congress 2024 in London.

Simultaneous publication in European Heart Journal, ehae578

Alessandro Sticchi

Author

Alessandro Sticchi

Structural cardiac interventions in patients with heart failure

27 Aug 2024

The review aims to address the unmet needs in heart failure (HF) management, particularly in patients where structural heart disease coexists with HF and limits the effectiveness of guideline-directed medical therapy (GDMT).

Alessandro Sticchi

Reviewer

Alessandro Sticchi

OCCUPI - Optical coherence tomography-guided coronary intervention in patients with complex lesions

03 Sep 2024

Alex Sticchi provides his take on the OCCUPI trial presented by Kim Byeong-Keuk at the ESC Congress 2024 in London.

Alessandro Sticchi

Author

Alessandro Sticchi

TRI.fr trial - Multicentric randomised evaluation of the transcatheter edge-to-edge repair in the treatment of severe isolated secondary tricuspid regurgitation

31 Aug 2024

Alex Sticchi provides his take on the results of the TRI.FR trial presented by Erwan Donal at the ESC Congress 2024 in London.

Alessandro Sticchi

Author

Alessandro Sticchi

PCRonline @ ESC Congress 2024: the interventional cardiology perspective!

26 Jul 2024

What was new and hot in interventional cardiology at #ESCCongress 2024!

Prognostic implications of residual tricuspid regurgitation grading after transcatheter tricuspid valve repair

18 Jun 2024

The take-home message for clinicians is that in the treatment of tricuspid regurgitation, the most frequent valvular disease alongside aortic stenosis, redefining procedural success as a function of the residual degree of TR is crucial.

Alessandro Sticchi

Reviewer

Alessandro Sticchi

Reviewer

Federico Bargagna

New York Valves 2024: Everything you need to know in a nutshell

11 Jun 2024

Alex Sticchi provides his take on the trials which were presented at New York Valves 2024, offering a concise summary, a short description and final thoughts. 

Alessandro Sticchi

Author

Alessandro Sticchi

Calcified lesions: one big challenge; several good options

17 May 2024 – From EuroPCR 2024

This session delves into the management of calcified coronary lesions, presenting various techniques and tools to address this common challenge. It covers topics such as the use of drug-coated balloons, rotational atherectomy, intravascular lithotripsy, and high-pressure non-compliant balloons. The session also includes a meta-analysis on the...

Calcified lesions: one big challenge; several good options

Antiplatelet de-escalation after complex PCI: when and how?

14 May 2024 – From EuroPCR 2024

It is now understood that ischemia is not the only risk to consider, as bleeding also plays a significant role. This is why de-escalation is now recommended for patients with complex PCI, as all de-escalation strategies reduce bleeding risk. Discover more about the three different de-escalation...

Antiplatelet de-escalation after complex PCI: when and how?

Percutaneous coronary intervention versus coronary artery bypass grafting in patients with left main disease with and without diabetes: findings from a pooled analysis of 4 randomized clinical trials

30 Apr 2024

This analysis shows that diabetic patients undergoing revascularization face substantially higher 5-year rates of all-cause mortality, myocardial infarction, repeat revascularizations, and stroke compared to non-diabetic patients.

Alessandro Sticchi

Reviewer

Alessandro Sticchi
Prof. Antonio Colombo

Reviewer

Antonio Colombo

Self-expanding versus balloon-expandable transcatheter aortic valve replacement in patients with small aortic annuli: Primary outcomes from the randomized SMART Trial

07 Apr 2024

Alessandro Sticchi interviews Howard C. Herrmann about the primary outcomes from the randomized SMART Trial which he presented at ACC.24 in Atlanta.

Patients with severe aortic stenosis and small aortic annuli, typically female and often underrepresented in clinical trials, are at risk for impaired valvular hemodynamics and associated...

Howard Herrmann

Author

Howard Herrmann
Alessandro Sticchi

Author

Alessandro Sticchi

PCRonline @ ACC.24 Scientific Sessions

22 Mar 2024

Live updates on a selection of major Late Breaking Clinical Trials of interest in interventional cardiology presented at the American College of Cardiology 2024 Scientific Sessions #ACC24

Effect of alcohol-mediated renal denervation on blood pressure in the presence of antihypertensive drugs: 3-month primary results from the TARGET BP I Randomized Trial

08 Apr 2024

Alessandro Sticchi interviews David E. Kandzari about the results of the Target Bp I Randomized Trial which he presented at ACC.24.

The trial reports mixed results on nerve ablation for high blood pressure with a modest but statistically significant difference in lowered blood pressure at 3 months,...

David Kandzari

Author

David Kandzari
Alessandro Sticchi

Author

Alessandro Sticchi

PARTNER 3 Low-Risk trial: 5-year insights on TAVI vs. SAVR outcomes

Alex Sticchi interviews Martin Leon about the five-year clinical and echocardiographic outcomes from the PARTNER 3 Low-Risk randomized trial, presented at the #TCT23 Congress.
The analysis reveals comparable outcomes for TAVI and SAVR, with nuanced differences favouring each approach. Prof. Leon emphasizes the importance of long-term data...

PARTNER 3 Low-Risk trial: 5-year insights on TAVI vs. SAVR outcomes

The mortality burden of untreated aortic stenosis

14 Nov 2023

This study, based on extensive real-world data, aimed to assess mortality rates across different untreated AS severities and AS treatment rates.

Alessandro Sticchi

Reviewer

Alessandro Sticchi

Reviewer

Giulia Costa