PCR Journal Club

The PCR Journal Club provides a selection of Literature Reviews of top interventional cardiovascular journals world-wide, selected and commented by the PCR Journal Club team.

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295 results

Clinical outcomes of proximal optimization technique (POT) in bifurcation stenting

22 Jun 2021

Find out more about what is considered the largest real-world registry data permitting analysis of very specific steps of bifurcation stenting, POT, and KBI.

Dr. Mirvat Alasnag

Reviewer

Mirvat Alasnag
Khaled F. Al-Shaibi

Reviewer

Khaled Al-Shaibi
Clinical outcomes of proximal optimization technique (POT) in bifurcation stenting

Aspirin versus clopidogrel for chronic maintenance monotherapy after percutaneous coronary intervention (HOST-EXAM): an investigator-initiated, prospective, randomised, open-label, multicentre trial

18 Jun 2021

The HOST-EXAM trial sought to define whether, after DAPT for PCI with DES, clopidogrel monotherapy is associated with improved outcomes compared with aspirin monotherapy.

Daniele Giacoppo

Reviewer

Daniele Giacoppo
Aspirin vs clopidogrel for chronic maintenance monotherapy after PCI: HOST-EXAM trial

Effect of CYP2C19 genotype on ischemic outcomes during oral P2Y12 inhibitor therapy: a meta-analysis

14 Jun 2021

Read more about this systematic review and meta-analysis which looked to ascertain if there is benefit in individualizing anti-platelet therapy on the basis of the CYP2C19 genotype. 

Reviewer

Samuel Mcgrath
Kalpa De Silva

Reviewer

Kalpa De Silva
Effect of CYP2C19 genotype on ischemic outcomes during oral P2Y12 inhibitor therapy: a meta-analysis

Moderate aortic stenosis in patients with heart failure and reduced ejection fraction

08 Jun 2021

The aim of this study was to determine the prognostic impact conferred by the presence of moderate AS on the outcomes of patients with HFrEF.

Luigi Biasco

Reviewer

Luigi Biasco
Moderate aortic stenosis in patients with heart failure and reduced ejection fraction

External applicability of the ISCHEMIA trial: an analysis of a prospective nationwide registry of patients with stable coronary artery disease

03 Jun 2021

This study aimed to delineate the external validity of the ISCHEMIA trial by applying the ISCHEMIA inclusion and exclusion criteria to an established cohort of patients with stable coronary disease in an observational setting.

Reviewer

Rupert Simpson
Kalpa De Silva

Reviewer

Kalpa De Silva
External applicability of the ISCHAEMIA trial: an analysis of a prospective nationwide registry of patients with stable coronary artery disease

EBC MAIN Late-breaking trial analysis

13 Jun 2021

Examination of the study methodology and results according to the PICOT principle, SWOT analysis and real-world applicability of the EBC MAIN trial presented at EuroPCR 2021.

EBC MAIN Late-breaking trial analysis

Cardiac mortality in patients randomised to elective coronary revascularisation plus medical therapy or medical therapy alone: a systematic review and meta-analysis

01 Jun 2021

The value of elective coronary revascularisation plus medical therapy over medical therapy alone in managing stable patients with coronary artery disease is debated. Hence, the authors reviewed all trials comparing the two strategies in this population to appraise whether revascularisation in addition to medical therapy affects...

Elad Asher

Reviewer

Elad Asher
Cardiac mortality in patients randomised to elective coronary revascularisation plus medical therapy or medical therapy alone: a systematic review and meta-analysis

Sex differences among patients with high risk receiving Ticagrelor with or without Aspirin after percutaneous coronary intervention: a subgroup analysis of the TWILIGHT randomized clinical trial

28 May 2021

This is a prespecified secondary sub-analysis of the TWILIGHT trial that seeks to shed light on the association of the different baseline risk factors, namely advanced age and significant renal dysfunction, with a higher bleeding risk in women.

Dr. Mirvat Alasnag

Reviewer

Mirvat Alasnag
Yasmin Anfi

Reviewer

Yasmin Hanfi
Sex differences among patients with high risk receiving Ticagrelor with or without Aspirin after percutaneous coronary intervention: a subgroup analysis of the TWILIGHT randomized clinical trial

Kidney Transplant List Status and Outcomes in the ISCHEMIA-CKD Trial

27 May 2021

ISCHEMIA-CKD is the only contemporary randomized trial that prospectively evaluated an upfront strategy of coronary angiography and revascularization plus optimal medical therapy (OMT) compared with OMT alone in patients listed for renal transplant.

Dr. Mirvat Alasnag

Reviewer

Mirvat Alasnag
Kidney Transplant List Status and Outcomes in the ISCHEMIA-CKD Trial

Multivessel PCI Guided by FFR or Angiography for Myocardial Infarction - FLOWER-MI

26 May 2021

This investigator-initiated randomised, open-label, multicentre trial compares FFR versus angiography guided strategies for treating non-culprit lesions in patients presenting with STEMI and multivessel coronary artery disease. The results of this study were released during ACC.21.

Nicola Ryan

Reviewer

Nicola Ryan
M. Pighi

Reviewer

Michele Pighi
Multivessel PCI Guided by FFR or Angiography for Myocardial Infarction - FLOWER-MI