PCR Journal Club

This study reports the prespecified 2-year follow-up results of the FAVOR III Europe trial, which compared quantitative flow ratio (QFR)-guided versus fractional flow reserve (FFR)-guided coronary revascularisation in patients with angiographically intermediate coronary stenoses.

FAVOR III Europe was a prospective, multicentre, randomised trial designed to evaluate whether...

Coronary microvascular dysfunction is increasingly recognised as a key determinant of outcomes beyond epicardial coronary disease. The FLOW-CMD registry provides new insights into its prevalence and prognostic impact in routine invasive practice.

In a secondary analysis of the randomised ORBITA-2 trial, focal coronary artery disease pattern as assessed by non-hyperaemic pressure wire pullback was associated with greater angina relief following PCI than diffuse pattern of disease.

Long-term evidence comparing PCI and CABG for unprotected left main coronary disease has been limited and sometimes conflicting. The 10-year results from the NOBLE trial now provide important clarity on all-cause mortality outcomes with both revascularisation strategies.

The RENOVATE-COMPLEX-PCI 5-year outcomes confirm the long-term durability of benefits seen with intracoronary imaging over angiography guided PCI in complex lesions.

The TUXEDO-2 trial sought to directly compare prasugrel versus ticagrelor in diabetic patients undergoing percutaneous coronary intervention (PCI), with the aim of clarifying whether the non-inferiority of ticagrelor could be established.

The present analysis compared major adverse cardiac events in patients with significant coronary stenosis (FFR ≤ 0.80 or visual stenosis ≥ 90 %) versus those with non-significant stenosis (FFR > 0.80).

In patients with severely calcified coronary lesions undergoing PCI, the BALI trial evaluated the benefit of the addition of intravascular lithotripsy to conventional lesion preparation on the composite endpoint of procedural failure and target vessel failure.

While FFR traditionally reflects the severity of a lesion at a fixed location, PPG incorporates the pullback profile, enabling a more comprehensive understanding of disease distribution.

This analysis from the XIENCE Short DAPT programme compared the safety and efficacy of one-month versus three-month DAPT in high-bleeding risk patients with and without diabetes mellitus (DM) following PCI with everolimus eluting stents (EES).