PCR Journal Club

According to the updated international revascularization guidelines, fractional flow reserve (FFR) and instantaneous wave-free period ratio (iFR) are proposed to dichotomize decision-making for ischemia detection in guiding percutaneous coronary intervention (PCI) of intermediate coronary stenosis.

The objective of the IAMI1 trial was to determine whether early influenza vaccination reduces the risk of cardiovascular events in patients admitted with an acute-MI or high-risk stable coronary artery disease in an adequately powered randomized control trial setting.

The aim of this study was to understand the impact of optical coherence tomography (OCT)-detected thin-cap fibroatheroma (TCFA) on clinical outcomes of diabetes mellitus (DM) patients with fractional flow reserve (FFR)-negative lesions.

This analysis highlights that, in appropriate hands, ISR CTO-PCI is safe, with similar success rates to de-novo CTO-PCI.

Find out more about the results of this analysis which suggest that operator experience may be an important effect modifier in ROTA-PCI.

The HOST-EXAM trial sought to define whether, after DAPT for PCI with DES, clopidogrel monotherapy is associated with improved outcomes compared with aspirin monotherapy.

This study aimed to delineate the external validity of the ISCHEMIA trial by applying the ISCHEMIA inclusion and exclusion criteria to an established cohort of patients with stable coronary disease in an observational setting.

The value of elective coronary revascularisation plus medical therapy over medical therapy alone in managing stable patients with coronary artery disease is debated. Hence, the authors reviewed all trials comparing the two strategies in this population to appraise whether revascularisation in addition to medical therapy affects...

ISCHEMIA-CKD is the only contemporary randomized trial that prospectively evaluated an upfront strategy of coronary angiography and revascularization plus optimal medical therapy (OMT) compared with OMT alone in patients listed for renal transplant.

Using patient-level data from the Disrupt CAD I, II, III and IV trials, this pooled analysis assesses the efficacy and safety of intravascular lithotripsy in de novo calcified coronary lesions.